Born in Budapest in a french family of protestant origins, Darier became Interne des Hôpitaux
de Paris in 1880 and head of a medical department in Saint-Louis hospital from 1909 till 1922.
Internationnaly known as the leader of the french dermatology, brillant clinician and pathologist, Darier described several dermatoses: follicular keratosis, acanthosis nigricans, dermatofibrosarcoma (Darier and Ferrand), erythema annularis, hypodermic sarcoids (Darier and Roussy), Darier's sign of the mastocytosis and give his name to a cutaneous disease identified in 1889 under the name of psorodermose folliculaire végétante (Darier's disease).
The textbook he published in 1909 was reedited many times in France as a classic of the dermatological literature and translated into german and english. At the age of 70, Darier was the chief editor of the greatest french dermatological encyclopedia: "Nouvelle Pratique Dermatologique", 8 volumes published in 1936.
Besides his professionnal activities, Darier was from 1925 till 1935 the mayor of Longpont-sur-Orge, a small town in the parisian suburban area.